Understanding protein folding with energy landscape theory. Part II: Quantitative aspects.

Understanding protein folding with energy landscape theory. Part I: Basic concepts.

Funnels, pathways, and the energy landscape of protein folding: a synthesis.

The understanding, and even the description of protein folding is impeded by the complexity of the process. Much of this complexity can be described and understood by taking a statistical approach to the energetics of protein conformation, that is, to the energy landscape. The statistical energy landscape approach explains when and why unique behaviors, such as specific folding pathways, occur ...

Energy landscape theory for cotranslational protein folding

Abstract Energy landscape theory describes how a full-length protein can attain its native fold after sampling only a tiny fraction of all possible structures. Although protein folding is now understood to be concomitant with synthesis on the ribosome there have been few attempts to modify energy landscape theory by accounting for cotranslational folding. This paper introduces a model for cotra...

Chemical physics of protein folding.

I n 2008, to the consternation of some, one of the editors of this special issue on the “Chemical Physics of Protein Folding,” was quoted as saying, “What was called the protein folding problem 20 years ago is solved” (1). One purpose of this special issue is to drive home this point. The other, more important purpose is to illustrate how workers on the protein folding problem, by moving beyond...

Energy Study at Different Temperatures for Active Site of Azurin in Water, Ethanol, Methanol and Gas Phase by Monte Carlo Simulations

The interaction between the solute and the solsent molecules play a crucial role in understanding the various molecular processes involved in chemistry and biochemistry, so in this work the potential energy of active site of azurin have been calculated in solvent by the Monte Carlo simulation. In this paper we present quantitative results of Monte Carlo calculations of potential energies of ...